I softblock new followers to this blog unless we have some kind of rapport.
DNI if you have no shifgrethor.
new glasses! there weren’t a lot of options 😂
graph of what being hungry is like with adhd
Keen-eyed "Junk World" readers will recognize the number six from this classic 2020 comic
"Two researchers in the US and Australia have discovered important mechanisms that prevent B cells from attacking the body’s own tissues in autoimmune diseases like arthritis, lupus, and multiple sclerosis—and in the process have won a prestigious prize.
Normally, the body’s immune system protects us from viruses, bacteria, and foreign substances. However, in autoimmune diseases, the immune system starts attacking tissues in the body instead.
Researchers had long tried to discover the cause of autoimmune diseases. But, Christopher Goodnow and David Nemazee, independently of each other, adopted a new approach.
They asked why we do not all develop these diseases. Their focus was on B cells which, together with white blood cells and T cells, are the building blocks of our complex immune system.
“They have given us a new and detailed understanding of the mechanisms that normally prevent faulty B cells from attacking tissues in the body, explaining why most of us are not affected by autoimmune diseases,” says Olle Kämpe, member of the Royal Swedish Academy of Sciences and chair of the Crafoord Prize committee that awarded the pair 6 million Swedish kronor ($600,000).
In recent years, physicians have started to experiment by using existing drugs to neutralize B cells for patients with severe autoimmune diseases, including lupus, rheumatoid arthritis, and multiple sclerosis, which has proven to be very effective at improving their quality of life.
Thanks to this year’s Crafoord Prize Laureates, we have gained fundamental new knowledge about what is happening in the immune system during autoimmune disease attacks.
“This also paves the way for development of new forms of therapies that eventually can cure these diseases—or might prevent them in the future,” said one professor of clinical immunology at the Royal Swedish Academy of Sciences...
More details from the video, since the article glosses over the particulars:
"The laureates discovered what is now called B cell tolerance.
When B cells develop in the bone marrow, not all of them are perfect. To remove the faulty ones, a mechanism starts, in which defective cells are programmed to destroy themself through apoptosis.
The laureates discovered two new mechanisms that are used if some of the bad cells are left. Re-editing, where the immune system alters the combination of receptors, and anergy, that silences B cells with self-reactive receptors.
The laureates were able to demonstrate that these mechanisms sometimes fail. This means that faulty B cells can cause an attack on the body's own tissues – leading to autoimmune diseases.
Thanks to the laureate’s discoveries, doctors like Anders Bengtsson soon felt able to start treating patients with lupus, arthritis, multiple sclerosis, and many other autoimmune diseases, with medicines that eradicated B cells.
Anders Bengtsson: "I'm very happy that B cells has gotten so much attention because of the laureates. I have seen my patients getting so much better and getting a better life."
Autoimmune patient: "Today, I feel very good. I really have hope in the research that it will revolutionise things and perhaps even cure it all. That’s what I want, hope for, and believe in.""
-Article via Good News Network, April 6, 2025. Video via The Royal Swedish Academy of Sciences, January 29, 2025.
Kuzu: every time I see that engraving I’m like why’s he serving. the cunty early modern rat catcher isn’t real and he can’t get you
Pip: he’s got Lazlo Cravensworth energy
watching dune 1984 on the big screen really emphasized the talent disparities between the actors in a really funny way
like of course you have patrick stewart kind of effortlessly subsuming all the atreides parts into his own by virtue of being a titan of delivery. then next you have brad dourif doing… whatever thing he is doing as piter, very convincingly. then there are the respected old hands like josé ferrer and max von sydow and sîan phillips for whom this movie is simply beneath them. and then… look. I love kyle machlachlan. I do. but he is so awkward in 90% of his scenes and it’s hysterically funny. kyle isn’t a bad actor but he’s got this inherent affable absurdity to him that feels really out of place on paul. and then there’s sting.
i think kyle gives an alien, blank slate performance much like the one keanu gives in the matrix that's kind of a stand-in for audience projection but you're completely correct that it's kind of a mismatch with many of the performances in the beginning two thirds of the movie
everett mcgill is however guilty of all the same sins if not more
Kyle’s thing for me is that he’s too weird to be a blank slate—he’s got this good-natured nostalgic airiness to him that makes him seem like you should maybe tie a string to his ankle as a precaution so he doesn’t float away. I think Lynch wrote Dale Cooper with this in mind because he plays it up and it works really well for the role. Something about Kyle engenders a sense of reluctant responsibility for him… which is a very incongruent vibe for Paul imho.
Part of it is just that his face is structured so that he always looks like he’s barely repressing a big doofy grin, so for all the initial scenes on Caladan he seems like he’s in on this big joke the adults don’t understand.
