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Review
doi: 10.1093/jnci/djn148.
Epub 2008 May 27.
Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?
Affiliations
- PMID: 18505970
- DOI: 10.1093/jnci/djn148
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Review
Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?
J Natl Cancer Inst.
.
Abstract
Despite nearly two decades of research investigating the use of dietary antioxidant supplementation during conventional chemotherapy and radiation therapy, controversy remains about the efficacy and safety of this complementary treatment. Several randomized clinical trials have demonstrated that the concurrent administration of antioxidants with chemotherapy or radiation therapy reduces treatment-related side effects. Some data indicate that antioxidants may protect tumor cells as well as healthy cells from oxidative damage generated by radiation therapy and some chemotherapeutic agents. However, other data suggest that antioxidants can protect normal tissues from chemotherapy- or radiation-induced damage without decreasing tumor control. We review some of the data regarding the putative benefits and potential risks of antioxidant supplementation concurrent with cytotoxic therapy. On the basis of our review of the published randomized clinical trials, we conclude that the use of supplemental antioxidants during chemotherapy and radiation therapy should be discouraged because of the possibility of tumor protection and reduced survival.
Comment in
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An apple a day may be safer than vitamins.J Natl Cancer Inst. 2008 Jun 4;100(11):770-2. doi: 10.1093/jnci/djn184. Epub 2008 May 27. J Natl Cancer Inst. 2008. PMID: 18505961 No abstract available.
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Re: Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?J Natl Cancer Inst. 2008 Sep 17;100(18):1334; author reply 1334-5. doi: 10.1093/jnci/djn279. Epub 2008 Sep 9. J Natl Cancer Inst. 2008. PMID: 18780866 No abstract available.
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Re: Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?J Natl Cancer Inst. 2008 Nov 5;100(21):1558-9; author reply 1559-1560. doi: 10.1093/jnci/djn346. Epub 2008 Oct 28. J Natl Cancer Inst. 2008. PMID: 18957669 No abstract available.
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Re: Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?J Natl Cancer Inst. 2009 Jan 21;101(2):124-5; author reply 125-6. doi: 10.1093/jnci/djn446. Epub 2009 Jan 13. J Natl Cancer Inst. 2009. PMID: 19141775 No abstract available.
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Re: Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?J Natl Cancer Inst. 2008 Nov 5;100(21):1558-9; author reply 1559-1560. doi: 10.1093/jnci/djn346. Epub 2008 Oct 28. J Natl Cancer Inst. 2008. PMID: 18957669 No abstract available.
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Re: Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?J Natl Cancer Inst. 2009 Jan 21;101(2):124-5; author reply 125-6. doi: 10.1093/jnci/djn446. Epub 2009 Jan 13. J Natl Cancer Inst. 2009. PMID: 19141775 No abstract available.
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