#OPENACCESS: Characterization of the pace-and-drive capacity of the human sinoatrial node: A 3D in silico study. Antoine Amsaleg, Jorge Sánchez, Ralf Mikut, and Axel Loewe.
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Biophysical Journal
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Biophysical Journal, the premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research.
Biophysical Journal’s Tweets
In the New and Notable "Collective organization from cellular disorder," Nathaniel Huebsch highlights the paper "The influence of entropic crowding in cell monolayers."
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New molecular dynamics simulation study by Ileri-Ercan and colleagues provides insight into the cellular uptake pathway of polystyrene-modified carbon nanotubes and their potential as drug delivery carriers. Read more here: bit.ly/3tt5BTH
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: ow.ly/WeB450LEUc6
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog:
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#OPENACCESS: Using a computational approach, Yan et al. reveal the molecular mechanisms involved in the regulation of nucleus size and the role of nuclear organization in shaping the cell response to environmental cues. More here: bit.ly/3DHFRsx
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#OPENACCESS: Gas vesicles arise as a tool to noninvasively visualize cellular function in vivo by ultrasound. et al. study how their geometry affects the sonomechanical properties of GVs and its impact on nonlinear ultrasound imaging.
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In the New and Notable "High-speed AFM reveals the dynamics of virus budding," Wouter H. Roos highlights the paper "Analysis of individual HIV-1 budding event using fast AFM reveals a multiplexed role for VPS4."
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New study by Sevier and Hormoz shows that differences in DNA twists (supercoiling) can play a role in polymerase activity and gene expression fluctuations. Check it out here: bit.ly/3Dm28L6
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#OPENACCESS: Phase separation in amino acid mixtures is governed by composition. David De Sancho.
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By applying ultra-fast atomic force microscopy and colleagues achieve real-time visualization of individual HIV budding events. Fantastic combination of technology, biology and data analysis.
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In new work, Choi and coworkers study DNA crystals self-assembled from synthetic DNA motifs, showing that their mechanical properties correlate to both the individual DNA molecules and the structural design. Read more here: bit.ly/3gQ4cn6
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#OPENACCESS: Strain stiffening of Ndc80 complexes attached to microtubule plus ends. Felix Schwietert, Vladimir A. Volkov, Pim J. Huis in ’t Veld, Marileen Dogterom, Andrea Musacchio, and Jan Kierfeld.
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In the New and Notable "Bacterial flotation devices enhance ultrasound imaging," Jacob Graham and Sinan Keten highlight the paper "Geometric effects in gas vesicle buckling under ultrasound."
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Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: ow.ly/S8hv50LqSyp
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FRAP - the gift that keeps on giving: Amanda Alexander and Sean Lawley extend the common FRAP analysis to accommodate intracellular, molecular anomalous subdiffusion - which can have a huge impact on the biological interpretation of FRAP experiments.
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In the New and Notable "Cholesterol’s balancing act: Defying the status quo," Milka Doktorova and Ilya Levental highlight the paper "Distribution of cholesterol in asymmetric membranes driven by composition and differential stress."
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#OPENACCESS: Understanding the separation of timescales in bacterial proteasome core particle assembly. Pushpa Itagi, Anupama Kante, Leonila Lagunes, and Eric J. Deeds.
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#OPENACCESS: ATP:Mg2+ shapes material properties of protein-RNA condensates and their partitioning of clients. .N. Amy Yewdall, Alain A.M. André, Merlijn H.I. van Haren, Frank H.T. Nelissen, Aafke Jonker, and Evan Spruijt ow.ly/9f3F50LetGg
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#OPENACCESS: Dual-wavelength stopped-flow analysis of the lateral and longitudinal assembly kinetics of vimentin. Lovis Schween, Norbert Mücke, Stéphanie Portet, Wolfgang H. Goldmann, Harald Herrmann, and Ben Fabry.
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In the New and Notable "Small molecules playing big roles: Tuning material properties of nucleolar condensates," Rai and Mukhopadhyay highlight the paper "ATP:Mg2+ shapes material properties of protein-RNA condensates and their partitioning of clients."
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New research by Nase and colleagues studies the adsorption and penetration behavior of fusion peptides at lipid membranes and their effect on the curvature of target membranes during cell entry of enveloped viruses. Check it out here: bit.ly/3CDLPJd
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#OPENACCESS: Skin permeability prediction with MD simulation sampling spatial and alchemical reaction coordinates. Magnus Lundborg, Christian Wennberg, Jack Lidmar, Berk Hess, Erik Lindahl,and Lars Norlén.
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#OPENACCESS: The Lab, including & strikes again: they take a deep look at the extracellular domain (size) and its impact on the dynamic behavior of membrane proteins, a mechanism unexplored until now.
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#OPENACCESS: Using a combination of molecular dynamic simulations and NMR, Salvi et al. develop an approach to study the dynamics of intrinsically disordered proteins (IDPs). Read more here: bit.ly/3S9put1
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In the New and Notable "It is in the flanks: Conformational flexibility of transcription factor binding sites," Remo Rohs et al. highlight the paper "Flexibility of flanking DNA is a key determinant of transcription factor affinity for the core motif."
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Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog:
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Sandrasegaram Gnanakaran and team explore how RAS-complex membrane orientation relates to the protein dynamics, by multiscale coarse-grained and all-atom molecular dynamics (MD) simulations both in solution and anchored to a model plasma membrane.
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By applying accelerated molecular dynamics simulations, Carla Mattos & team investigated in which way isoform-specific residues between HRas, KRas, and NRas affect the functionality and activity of these important signaling effectors.
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By developing a new theoretical framework, Teimouri et al. study cancer initiation dynamics and the pathways involved in tumor formation in their recently published work. More here: bit.ly/3dXLBod
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"...cancer cells are plastic..." use different extracellular matrix environments, brillouin microscopy & optical tweezers to probe cancer cells’ ability to adopt multiple mechanical states and their response to disturbances.
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New research by Paramanathan and colleagues probes the importance of chirality in the binding of small molecule intercalators to DNA and the resulting structural properties. Check it out here: bit.ly/3C50mO3
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In the New and Notable "Cells in the mechanical spotlight," Max A. Hockenberry and Wesley R. Legant highlight the paper "Multimodal microscale mechanical mapping of cancer cells in complex microenvironments."
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In new work, Kandy and Radhakrishnan developed a model to analyze how crowding of biopolymers at cell surface decides cell membrane shape and cell-cell communication. Read more here: bit.ly/3fDaUMO
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Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog:
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Using NMR, Yu et al study the electrostatic influences of nucleic acids on different cations, data useful for examination of computational models for electrostatic interactions or ion solvation. More here: bit.ly/3BvutOq
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In the New and Notable "The soft breeze of the cation atmosphere around DNA," Fabien Ferrage and Damien Laage highlight the paper "Diffusion NMR-based comparison of electrostatic influences of DNA on various monovalent cations."
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Tan and colleagues have developed a modeling resource “FebRNA�? for building RNA 3D structures such as pseudoknots and branched junctions. Check it out here: bit.ly/3DsJSS6
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In the New and Notable "Interfacial structure of pulmonary surfactants revisited: Cholesterol and surface pressure effects," Tommy Nylander highlights the paper "Effects of cholesterol on the structure and collapse of DPPC monolayers."
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