okay so i work in the deli of a grocery store, yeah? and today i got this guy who came up with his two twin children, around five years old. he walks up to the counter, carrying one kid in each arm, and loudly goes “oh, no, i forgot what i wanted!” and turns to the boy in his left arm and, in a perfect blues clues style voice, goes “caleb, do you remember what i wanted?” and the boy goes “half pound of yellow cheese!”
i, obviously, say “you’ve got it little sir!” and slice up half a pound of yellow american cheese, handing it to the little boy, who looks it over, nods, and tucks it in his lap.
then the man goes “well, we can’t just have cheese on our sandwiches. but what else can we put on there?” and the little gurl in his other arm goes “half pound of ham!” so i nod and say “yes ma'am! what kind?” and she points at a random cut of turkey, so her father nods and says “like she said, honey ham!” i cut half a pound of honey ham, hand it to the little lady, she looks it over, nods and puts it in her lap.
then the man goes “now, what should we have for the side?” and the kids both simultaneously start cheering “macking cheese!!!” and the man spins on his heel and marches off, presumably to find the macking cheese.
later, the little boy comes wandering back to the counter while his father looks on and loudly and proudly proclaims that he wants to know where the mustard is. i point him to the correct aisle, he nods, says “thank you mister deli woman” and walks away.
this company is so frustratingly misleading. They did not bring back the direwolf (Aenocyon dirus). They modified a modern grey wolf (Canis lupus) into having some direwolf morphology. There has been no de-extinction. This is pure hype slop. As a friend said “these are dire wolves the same way La Croix is a fruit”.
I still think this tech has the potential to be helpful in a conservation context…. but it says a A LOT that these “dire wolves” look far more like something you’d see in Game of Thrones than any of the most likely reconstructions proposed by scientists who’ve studied the fossil record.
These pups might get more robust as they age, but right now I’m not seeing anything to get excited about. I just can’t help but suspect that this species was chosen specifically bc the public already has the idea of “dire wolf = gray wolf + big”, and that this company is using relatively minor CRISPR editing to give the false impression that they’re recreating anything that might have conceivably lived 10,000 years ago.
Again, I think this tech is interesting and merits further development (and if jurassic park is the only way they can do that, then, I guess that’s what’s happening), but it’s still extremely misleading to parade these animals around like they’ve actually 100% cloned a dire wolf.
Really reminds me of Jurassic Park. In the books, Crichton made it very clear that they didn’t actually clone dinosaurs. They just combined DNA to make an animal that looked like what people EXPECT a dinosaur to look like, because it turned out that actual cloned dinosaurs were really quite dull and spent most of their time hiding.
Aencyon dirus isn’t closely related to modern wolves at all either so it doesn’t make any sense to start with a gray wolf. (According to wikipedia they were isolated from the gray wolf lineage for over 5 million years.) we thought they were in genus Canis but turns out it was just convergent evolution and they are a whole other thing
now that I actually read the article, I realize that the lede was buried– they genetically modified this wolf, and they also cloned 4 critically endangered red wolves
I think the TIME article is really irresponsible in acting like the pups are dire wolves when they don’t contain any dire wolf DNA. The “dire wolf” pups are literally just gray wolve engineered to look more like the creatures on Game of Thrones (literally–one of the pups is named Khaleesi)
I remain cautiously optimistic though, because it seems like they are doing actually useful research for preserving existing animals and then putting a Jurassic Park type spin on it for the media.
The Dire wolf thing honestly might just be an attention-grabber to get money off of people that know nothing about ecosystems, and the red wolf might be the actual real purpose of the research. If they’ve figured out the genetic basis of body size and certain “wolfy” behaviors in wolves, they could make it possible to bring coyote-red wolf hybrids into the red wolf breeding pool without sacrificing the wolf traits
Y'all, just think about guys like Elon Musk. Rich tech bros with a 5 yr old boy’s idea of what is cool. This stuff is perfectly calibrated to siphon off some of those techbro’s billions, while on the side, being helpful to conservation
Just look at the traits of the altered pups that are highlighted in the article: snout, jaw and limb thickness and heaviness, vocalizations, body size. All key traits that separate red wolves and coyotes.
Here’s what the article says:
Recently, Bridgett vonHoldt, a Colossal scientific adviser and an associate professor of ecology and evolutionary biology at Princeton University, and Kristin Brzeski, an associate professor of wildlife science and conservation at Michigan Tech, discovered populations of canids along the coasts of Louisiana and Texas whose DNA included both coyote genes and red wolf ghost alleles. The four red wolves the Colossal scientists created used that natural genetic reservoir to produce what they call the first Ghost Wolf, with an eye to eventually fortifying the red wolf species with more such young carrying a variety of genes.
They’re using this technology to bring genetic diversity from red wolf/coyote hybrids back into the red wolf gene pool. As soon as I read “red wolves” I suspected this might be what was happening, and I was right. This could help fix the genetic bottleneck in red wolves and make a real chance for the species to actually return.
this approach is honestly genius
It’s like those researchers who have made huge strides in lake ecology with funding they get by “searching for the Loch Ness Monster”
yup exactly
just a quick search of this Bridgett vonHoldt demonstrates that she is a BIG DEAL in the world of canine evolution and genomics. she’s worked on groundbreaking publications that have hundreds of citations in some of the most renowned scientific journals. She’s the real deal.
whether Colossal is serious and knowledgeable or not, they’re working with people who are.
Watching the mummy 1999 for shits and giggles, thought it’d be fun to bitch abt the inaccurate hieroglyphs now that I know smth abt all that. Disappointed and disgusted to find out that they hired an egyptologist consultant and the hieroglyphs are actually well done. Night ruined
Wait that’s so fucking awesome I wish I was cataloguing rocks for egyptologists
