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Bioinformatics

Decoding the language of messenger RNA

Nature Methods volume 23, pages 880–881 (2026) Cite this article

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The open-source Orthrus RNA language model maps evolutionary patterns across mammalian species to predict key mRNA properties, advancing RNA biology research.

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Fig. 1: RNA language models learn sequence-to-property relationships and can be used for RNA therapeutic design.
The alternative text for this image may have been generated using AI.

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Author information

Authors and Affiliations

  1. mRNA Center of Excellence, Sanofi, Waltham, MA, USA

    Jun Wang, Dinghai Zheng & Vikram Agarwal

Authors
  1. Jun Wang
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  2. Dinghai Zheng
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  3. Vikram Agarwal
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Corresponding author

Correspondence to Vikram Agarwal.

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Competing interests

J.W., D.Z., and V.A. are employees of Sanofi and may hold shares and/or stock options in the company.

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Wang, J., Zheng, D. & Agarwal, V. Decoding the language of messenger RNA. Nat Methods 23, 880–881 (2026). https://doi.org/10.1038/s41592-026-03032-x

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